村田 一郎¹, 秋山 龍二¹, 金 衡仁¹, 小西 泰¹, 伊東 紘一²

Ichiro MURATA¹, Ryuji AKIYOSHI¹, Kojin KIN¹, Yutaka KONISHI¹, Koichi ITO²

¹東京共済病院内科, ²自治医科大学臨床病理学教室

¹Department of Internal Medicine, Tokyo Kyosai Hospital, ²Department of Clinical Pathology, Jichi Medical School

キーワード : fuzzy echoes, moyamoya ehcoes, blood mixtures, red blood cells, red blood cell aggregation

In order to clarify the source of so called "moyamoya echoes", the following experimental study was carried out.
Six kinds of blood mixtures were prepared and sealed in a rubber balloon as follows:
(1) A suspension of washed type B red blood cells.
(2) Washed type B red blood cells mixed with diluted type O plasma.
(3) Stored type B whole blood mixed with stored type O whole blood.
(4) Washed type B red blood cells mixed with a serum from a patient with multiple myeloma.
(5) A mixture of washed type B red blood cells and a clot.
(6) Washed type B red blood cells mixed with room air.
The balloon was immersed in degassed water and then two-dimensional and M-mode echograms were recorded by means of an immersion method. At the same time, the specimens taken from the mixtures were microscopically examined. Weak fuzzy echoes were seen in (1), (2) and (4). Strong fuzzy echoes, resembling clinical moyamoya echoes, were observed in (3), and remarkable aggregation of red blood cells was revealed microscopically in the specimen from this mixture.
It is concluded that aggregation of red blood cells significantly contributes to the formation of clinically observed moyamoya echoes.