Yuji NAKAJIMA¹, Taiichi SATOH², Koh ICHIHASHI³, Toshihiro KURAMATSU³, Sadayuki YANO³, Masayoshi YANAGISAWA³, Kouichi ITOH⁴, Junko MAEDA⁵

¹Departments of Pediatrics, Furukawa Nikko Sougou Hospital, ²Obstetrics and Gynecology, Furukawa Nikko Sougou Hospital, ³Departments of Pediatrics, Jichi Medical School, ⁴Clinical Pathology, Jichi Medical School, ⁵Department of Pathology, Dokkyo Medical School

キーワード : Prenatal ultrasonography, Holoprosencephaly, Alobar type

Holoprosencephaly is a congenital malformation that affects both brain and facial structures. We report here a case of alobar holoprosencephaly with cebocephaly diagnosed on the basis of prenatal ultrasound examination. The characteristic findings of this disorder included a large accumulation of central cranial fluid (a monoventricular cavity lacking ventricular horns), and a fused thalamus at the floor of this cavity. The cortex was displaced rostrally, and the falx cerebri, the septum pellucidum and the corpus callosum were absent on the ultrasound examination. The prenatal diagnosis of this disorder may be useful for the prenatal and neonatal management.