三木 信彦¹, 斎藤 公明¹, 廣内 恒¹, 上野 洋², 佐野 博志², 横田 慶之², 福崎 恒²

Nobuhiko MIKI¹, Komei SAITO¹, Hisashi HIROUCHI¹, Hiroshi UENO², Hiroshi SANO², Yoshiyuki YOKOTA², Hisashi FUKUZAKI²

¹公立日高病院内科, ²神戸大学医学部第一内科

¹Internal Medicine, Hidaka Hospital, ²The First Department of Internal Medicine, Kobe University School of Medicine

キーワード : Hypertension, Echocardiography, Antihypertensive therapy, Diastolic function

To assess the effect of long term antihypertensive therapy on left ventricular hypertrophy and function, we studied 31 patients with essential hypertension for a period of 8 years and 30 normotensive controls. Using two dimensional M-mode echocardiogram and phonocardiogram, we evaluated the changes in left ventricular (LV) wall thickness [IVST+PWT], LV mass index [LVMI], systolic time intervals [STIs: preejection period, ejection time, Weissler index], isovolumic relaxation time [IVRT], left atrial emptying index [AEI] and ejection fraction [EF].
Before treatment, IVST+PWT, LVMI and IVRT were significantly higher [pThe 8 years antihypertensive therapy resulted in significant reductions in mean blood pressure (116.6±13.5 to 105.6±10.5 mmHg, mean ± SD, p2, pThese results indicate that the adequate long term blood pressure control is accompanied by an improvement of early diastolic left ventricular function in association with the regression of hypertrophy.