竹内 陽史郎, 横田 慶之, 三木 隆, 津村 泰弘, 中谷 真, 上野 洋, 野村 秀樹, 薄木 成一郎, 江本 隆一, 福崎 恒

Yoshiro TAKEUCHI, Yoshiyuki YOKOTA, Takashi MIKI, Yasuhiro TSUMURA, Makoto NAKATANI, Hiroshi UENO, Hideki NOMURA, Seiichirou USUKI, Ryuichi EMOTO, Hisashi FUKUZAKI

神戸大学第一内科

The 1st department of Internal Medicine, Kobe University School of Medicine

キーワード : Dilated cardiomyopathy, Left atrial function, Left atrial systolic time intervals, Angiotensin II loading, Doppler echocardiography

To assess the impairment of left atrial (LA) booster pump function in dilated cardiomyopathy (DCM), 10 patients with DCM were echocardiographically examined before and during angiotensin II (AT II) infusion. We obtained end-diastolic and end-systolic left ventricular dimensions (Dd, Ds), percent fractional shortening (% FS) and the LA dimension before atrial contraction (LADa) using M mode echocardiography, peak velocities during the rapid filling phase (R) and during atrial systole (A), A/R, and the left atrial systolic time intervals indexes, including the corrected left atrial pre-ejection period (APEPc) and the left atrial ejection time (AET) for transmitral flow using pulsed Doppler echocardiography. After AT II loading, the heart rate did not change. Systolic and diastolic blood pressures (104±9.8 mmHg → 135±18 mmHg, P