Daravash B. TATA, Floyd DUNN

Bioacousitc Research Laboratory, University of Illinois

キーワード : Ultrasound interaction, Hematoporphyrin, Sarcoma, Rate Kinetics

Enhanced in vitro sarcoma cell reduction during the application of ultrasound with the photo activated anti-cancer drug hematoporphyrin [HP] has been reported in which the cell damage enhancements are attributed to short lived singlet oxygen molecules generated via ultrasonically activated HP molecules. In the present communication, first order rate kinetics are utilized to reveal the dominant role HP plays in reducing the population rapidly. The first order rate constant of in vitro population reduction due to the presence of HP is found to be directly proportional to HP concentration, and to the intensity of the sonication. The total fractional in vitro population reduced by HP is found to obey a power law in which the exponent is a linear function of the ultrasound intensity and a non-trivial function of the concentration of HP.