辻田 直隆¹, 立花 克郎², 山下 信哉¹

Naotaka TUJITA¹, Katsuro TACHIBANA², Nobuya YAMASHITA¹

¹福岡大学医学部第一解剖学教室, ²福岡大学医学部第一内科

¹The First Department of Anatomy, Fukuoka University School of Medicine, ²First Department of Internal Medicine, Fukuoka University School of Medicine

キーワード : Ultrasound Exposure, Transdermal Drug deliery, Mechanism

A hairless mouse in a beaker was exposed to 48 kHz ultrasound and pyoktanin blue. Macro and microscopic examinations were carried out and compared with groups without ultrasound exposures. Skin subjected to ultrasound showed both a diffused and localized penetration of the dye. This suggested that ultrasound affected the barrier function of the stratum corneum. It was further suggested that local penetration of the dye may be due to the structural character of the skin.