朴 勤植¹, 土居 忠文², 斎藤 昇³

Keunsik PARK¹, Tadafumi DOI², Noboru SAITO³

¹大阪市立大学医学部臨床検査医学, ²高知医科大学附属病院検査部, ³高知医科大学附属病院老年病科

¹Clinical Laboratory Medicine Osaka City University Clinical Laboratoty, ²Department of Clinical Laboratory, Kochi Medical School, ³Department of Geriatrics, Kochi Medical School

キーワード : Ultrasonic duplex system, The impairment of periphral circulation in diabetes mellitus, Blood flow of radial artery, Cold water exposure

To evaluate the dysfunction of the peripheral circulation in diabetic patients, we quantitatively measured the radial artery flow, using a B-mode combined pulsed Doppler system (Duplex system). In a simulated vessel model study, the ratio of Vmean/Vmax was found to be 0.655 and this ratio varied with the diameter of the vessels and the velocity of the flow. In healthy subjects, the diameter of the radial artery showed little change, but the velocity was reduced with aging, thereby indicating that the blood flow volume decreased. In 21 diabetic patients the diameter of the radial artery was 2.3±0.5 mm (mean ±SD), the velocity was 5.8±2.1 cm/sec and the blood flow volume was 15.8±9.6 ml/min, while these were 2.4±0.3 mm, 8.5±2.4 cm/sec and 23.7±11.2 ml/min in healthy older patients, respectively. There was no significant difference in the diameter of the radial artery of healthy subjects and diabetic patients. The velocity and blood flow volune in diabetic patients were less than in healthy subjects. After cold water exposure for 10 seconds, the change in the blood flow volume was examined. The diameter of the radial artery was not changed after exposure to cold in either healthy subjects or diabetic patients. The velocity and blood flow volume were transiently decreased, and recovered within several minutes in diabetic patients as well as in healthy subjects. However, the blood flow volume after recovery in diabetic patients remained as low as it had been before the test.
Applying the ultrasonic duplex system, we confirmed that diabetic patients have a lowewd blood flow velocity in comparatively small arteries such as the radial artery.