松山 裕宇, 菱田 仁, 岩瀬 正嗣, 安井 直, 福井 雅子, 玉垣 浩美, 武田 京子, 安藤 俊量, 野村 雅則, 森本 紳一郎, 水野 康

Hiroyuki MATSUYAMA, Hitoshi HISHIDA, Masatsugu IWASE, Tadashi YAUSI, Masako FUKUI, Hiromi TAMAGAKI, Kyoko TAKEDA, Toshikatsu ANDOH, Masanori NOMURA, Shin-ichirou MORIMOTO, Yasushi MIZUNO

藤田保健衛生大学内科

Fujita health university school of medicine

キーワード : Intravascular ultrasound, Atherosclerosis, Rabbit

The development of intravascular ultrasound (IVUS) has enabled us to observe atherosclerotic lesions in vivo. The purpose of this study was to assess the usefullness of IVUS in evaluating early stage atheromatous lesions in vivo in an atherosclerotic rabbit aorta by comparison with microscopic findings. To induce atheromatous changes endotherium was removed by withdrawing a no. 4 French Fogarty catheter from the thoracic to abdominal aorta in male, white rabbits after 4 weeks of high-cholesterol feeding. Three male rabbits fed normally were used as the control group. Serum cholesterol levels were significantly higher in the atherosclerotic rabbits than in the control group (p