別所 健史¹, 坂本 博三², 平 省三³, 香山　 浩二¹

Takefumi BESSHO¹, Hiromi SAKAMOTO ², Shozo TAIRA ³, Koji KOYAMA ¹

¹兵庫医科大学附属病院産婦人科, ²兵庫医科大学附属病院臨床遺伝部, ³市立川西病院産婦人科

¹Department of Obstetrics and Gynecology, Hyogo Medical College, ²Department of Clinical Genetics, Hyogo Medical College, ³Department of Obstetrics and Gynecology Kawanishi Municipal Hospital

キーワード : Abortion, Blighted ovum , Chromosomal abnormalities, Transvaginal ultrasonography

The incidence of histopathologically defined blighted ovum has been variously reported as 49% to 90% of all spontaneous abortions. Although most cases of blighted ovum have been shown to be karyotypically abnormal, the details of those cases diagnosed by transvaginal ultrasonography remain obscure. Here we attempt to analyze the incidence of chromosomal abnormalities in blighted ovum and embryonic death. Abnormal karyotypes were obtained in 13 (68%) of 19 cases of blighted ovum, and in 16 (70%) of 23 cases of embryonic death. The proportion of abortuses with chromosomal abnormalities of low fetal viability potential among abnormal karyotypes was significantly higher in blighted ovum (85%) than that in embryonic death (25%) (p