松尾 裕英¹, 高橋 則尋¹, 由良 高文¹, 宮武 邦夫², 中谷 敏², 石蔵 文信², 阿部 圭志³, 今井 潤³, 笹生 俊一⁴, 笠井 豊⁴, 杉崎 徹三⁵, 戸塚 大輔⁴, 川内 章裕⁶, 高元 俊彦⁷, 吉田 マリ子⁷, 羽田 勝征⁸, 伊藤 敦彦⁸, 加藤 和三⁹, 澤田 準⁹, 森安 史典¹⁰

Hirohide MATSUO¹, Norihiro TAKAHASHI¹, Takafumi YURA¹, Kunio MIYATAKE², Satoshi NAKATANI², Fuminobu ISHIKURA², Keishi ABE³, Yutaka IMAI³, Shunicni SASO⁴, Yutaka KASAI⁴, Tetsuzo SUGISAKI⁵, Daisuke TOTSUKA⁴, Akihiro KAWAUCHI⁶, Toshihiko TAKAMOTO⁷, Mariko YOSHIDA⁷, Yoshiyuki HADA⁸, Nobuhiko ITO⁸, Kazuzo KATO⁹, Hitoshi SAWADA⁹, Fuminori MORIYASU¹⁰

¹香川医科大学第2内科, ²国立循環器病センター内科心臓部門, ³東北大学第2内科, ⁴国立療養所宮城病院第2内科, ⁵昭和大学腎臓内科, ⁶昭和大学外科, ⁷佐々木研究所附属杏雲堂病院循環器科　, ⁸JR東京総合病院循環器内科, ⁹心臓血管研究所附属病院内科, ¹⁰京都大学第1内科, ¹¹神戸市立中央市民病院循環器内科, ¹²愛媛大学薬理学, ¹³国立循環器病センター, ¹⁴康済会病院

¹Second Department of Internal Medicine, Kagawa Medical School, ² , ³ , ⁴ , ⁵ , ⁶ , ⁷ , ⁸ , ⁹ , ¹⁰ , ¹¹ , ¹² , ¹³ , ¹⁴

キーワード : Color Dopper flow imaging, Contrast echo, Kidney, Ultrasound

吉川　純一　11
赤土　正洋　11
小川　暢也　12
尾前　照雄　13
山村　秀夫　14
We conducted a dose-finding study of the effect of SH/TA 508, an ultrasound contrast agent, on signal enhancement in color Doppler flow imaging in the kidney. The safety and usefulness of this agent were also evaluated. Signal enhancement effect at a scale of 2+ or higher was obtained from more than 70% of the 67 evaluable patients studied. Concentrations of 300 or 400 mg/ml enhanced signals more effectively than a concentration of 200 mg/ml. Better signal enhancement was obtained in patients whose creatinine value was less than 1.5 mg/dl, when results were layered and analyzed by creatinine value (