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英文誌(2004-)

Journal of Medical Ultrasonics

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1996 - Vol.23

Vol.23 No.09

Original Article(原著)

(0663 - 0668)

成人T細胞白血病細胞に対するポルフィマーナトリウムを用いた音響化学療法の効果

Selective Elimination of Adult T-Cell Leukemia Cells Using Photosensitizers Followed by Ultrasound Treatment

内田 俊毅, 立花 克郎, 森岡 英次, 久野 修資

Toshiki UCHIDA, Katsuro TACHIBANA, Eiji MORIOKA, Shusuke HISANO

福岡大学第1内科

First Department of Internal Medicine, School of Medicine, Fukuoka University

キーワード : Adult T-cell leukemia, MT-2 cell, Porfimer sodium (Photofrin), Sonodynamic chemotherapy, Ultrasonics

We evaluated sonodynamic chemotherapy with porfimer sodium (Photofrin; Pf) on blood tumor cells in order to compare cell-killing effects among adult T cell leukemia MT-2 cell lines: normal peripheral mononuclear cells (PMNCs) and PMNCs from ATL patients. Cells were exposed to 450-KHz ultrasound at an intensity of 0.3 W/cm2. Survival rates of MT-2 cells exposed to ultrasound for 80 seconds were 59.8±8.0%, whereas survival in ultrasound combined with 50 and 100 μg/ml of Pf was 37.8±8.2% and 20.5±9.0%, respectively. There was a significant difference cell survival between the group exposed to ultrasound alone and the group exposed to ultrasound in combination with Pf (P