Yumiko SATO, Hiroaki SATO, Masato FUNASAKO, Masahiro OHATA

Department of Internal Medicine, Wakayama Medical College Kihoku Hospital

キーワード : Chronic liver disease, Color Doppler ultrasonography, Exercise load, Hepatic blood flow, ICG test

We used color Doppler ultrasonography to measure portal blood flow before and after administration of exercise ranging from 50% to 55% or 60% to 65% of maximal heart rate in patients with chronic liver diseases; we also used the indocyanine green (ICG) test to determine hepatic blood flow during exercise. Information on portal and hepatic blood flow during and after exercise thus obtained was then analyzed. There was no decreases in portal blood flow after exercise that maintained 50% to 55% max HR in the normal control (NC), chronic hepatitis (CH), or liver cirrhosis (LC) groups. Portal blood flow after exercise that maintained 60% to 65% max HR was decreased to 80% of that at rest in the NC and CH groups. Vascular sectional area was significantly decreased after exercise that maintained 60% to 65% max HR. Portal blood flow may be affected by chages in vascular sectional area. There was no delayed recovery of portal blood flow after completion of exercise that maintained 60% to 65% max HR in the CH group. Next we used the ICG test to measure hepatic blood flow at rest, during walking, and in the standing position in the CH patients. Hepatic blood flow during exercise that maintained 50% to 55% max HR was higher than that at rest or in the standing position. Exercise that maintains 50% to 55% max HR may have no negative effect on portal or hepatic blood flow of patients with chronic liver diseases. Rest should not be emphasized unneccesarily from the perspective of quality of life of patients with chronic liver diseases; lowintensity exercise, including walking, should be recommended.