Yasuyoshi IWATA¹, Kanji KOJIMA², Makoto ISHIDA³, Yukinobu NAKAMURA³, Toshihiko ISHIDA¹, Jiro TAKAHARA¹

¹First Department of Internal Medicine, Kagawa Medical University, ²Department of Radiology, Kagawa Rosai Hospital, ³Department of Internal Medicine, Kagawa Rosai Hospital

キーワード : Acceleration index, Diabetic nephropathy, Doppler color flow imaging, Pulsatility index, Resistive index

We used Doppler color flow imaging to study resistive index (RI), pulsatility index (PI), and acceleration index (AI), indexes of peripheral vascular impedance, in 106 cases of diabetic nephropathy. Although RI and PI were strongly correlated, no such correlation was found between RI or PI and AI. RI and PI increased as nephropathy developed, attaining values even higher than those found in the early stage of overt nephropathy before creatinine level rose and 24-hour creatinine clearance fell. This suggests that RI and PI may prove to be useful indexes that can be used before the late phase of overt nephropathy, an irreversible stage in the therapy of diabetic nephropathy.