吉崎 秀夫¹, 竹内 和男², 奥田 近夫², 本庶 元², 山本 貴嗣², 高良 哲郎³, 高森 頼雪⁴

Hideo YOSHIZAKI¹, Kazuo TAKEUCHI², Chikao OKUDA², Hajime HONJYO², Takatugu YAMAMOTO², Tetuo KORA³, Yoriyuki TAKAMORI⁴

¹札幌徳州全病院消化器科, ²虎の門病院消化器科, ³東邦大学第2内科, ⁴帝京大学内科

¹Department of Gastroenterology, Sapporo Tokusyukai Hospital, 18-4-10 Sakaedori Shiroishi-ku Sapporo-shi 003-0021, Japan, ²Department of Gastroenterology, Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470, Japan, ³Second Department of Internal Medicine, Toho University, School of Medicine 5-21-16 Oomorinishi Oota-ku Tokyo 143-8540, Japan, ⁴Department of Internal Medicine, Teikyo University, School of Medicine 2-11-1 kaga Itabashi-ku Tokyo 173-8605, Japan

キーワード : Autoimmune pancreatitis, Chronic pancreatitis, Sjögren syndrome, Steroid, Ultrasonography

The concept of autoimmune pancreatitis has recently been established, and ultrasonographic findings we obtained from five cases consistent with autoimmune pancreatitis are reported here. Case 1 a 77-year-old man, was admitted complaining of loss of body weight. Serum hepatobiliary enzymes and γ-globulin levels were elevated, and antinuclear antibody was positive. Abdominal ultrasonography showed dilatation of the intrahepatic bile duct, wall thickening of the common bile duct and hypoechoic swelling of the pancreatic head and body. ERCP revealed multiple stenosis of the intra- and extra-hepatic bile ducts, and diffuse irregular narrowing of the main pancreatic duct. The patient complained of thirst, and the minor salivary gland was examined histologically. Our diagnosis was Sjögren syndrome accompanied by sclerosing cholangitis and a pancreatic lesion. Obstructive jaundice also developed, and PTCD was therefore performed. Both the pancreatic swelling and multiple stenosis of the bile duct improved after steroids were administered. Case 2, a 71-year-old man, was admitted with jaundice. Abdominal ultrasonography showed hypoechoic swelling of the pancreas; ERCP showed stenosis of the common bile duct in the pancreatic head region and diffuse irregular narrowing of the main pancreatic duct. Histological examination of the minor salivary gland suggested Sjögren syndrome. Steroids were therefore administered because the presence of both hyper-γ-globulinemia and positive antinuclear antibody suggested involvement of the autoimmune mechanism. Steroid therapy improved the jaundice as well as the findings from the cholangiograms and pancreatograms. We also encountered three similar cases, all consistent with the concept of autoimmune pancreatitis. The ultrasonographic findings of the pancreatic lesion (1) showed them as homogeneous and markedly hypoechoic areas and, (2) visualized the main pancreatic duct in the lesion, which allowed for a differential diagnosis of the neoplastic lesions. (3) Steroid therapy effectively decreased the hypoechoic area; in some cases, however, a hypoechoic area remained around the main pancreatic duct.