大川井 宏明¹, 仁田 桂子², 高橋 和彦³, 片平 美明², 薗部 太郎¹, 藤田 雅史², 中島 博行², 許 立慶¹, 仁田 新一¹

Hiroaki OKAWAI¹, Keiko NITTA², Kazuhiko TAKAHASHI³, Yoshiaki KATAHIRA², Tarou SONOBE¹, Masashi FUJITA², Hiroyuki NAKAJIMA², Liqing XU¹, Shin-ichi NITTA¹

¹東北大学加齢医学研究所病態計測制御研究分野, ²東北厚生年金病院循環器科, ³宮城県立瀬峰病院循環器科(現在:高橋ハートクリニック)

¹Institute of Development, Aging, and Cancer, Tohoku University, ²Department of Cardiovascular Diseases, Tohoku Kosei Nenkin Hospital, ³Department of Cardiovascular Diseases, Miyagi Prefectural Semine Hospital

キーワード : Coronary artery disease, Excursion, Regional wall motion abnormalities, Stress echocardiography, Wall thickness

To improve the evaluation of regional wall motion abnormalities (WMA) during stress echocardiography, the parameters of the wall thickness change, excursion and stroke volume, with time-dependent changes in two regional portions of the interventricular septum and the posterior wall evaluated with M-mode ultrasonography are proposed. Response to the dipyridamole stress test was studied in two normal subjects and eight subjects with coronary disease. Regional wall motion and stroke volume were measured, and the results were compared with results obtained with coronary angiography, 2-D echography, and radioisotope scintigraphy. In normal subjects, these parameters showed only monotonous change with the passage of time. In patients with coronary artery disease, however, discrepancy in wall thickness and excursion between the interventricular septum and the posterior wall appeared within 1 to 3 minutes after the start of the test. Thus, despite the limitation of the examined area imposed by use of M-mode, the motion of the interventricular septum and the posterior wall described the detailed WMA and an ischemic state.