渡辺 さち子¹, 鈴木 奈美子¹, 工藤 亜津子¹, 鈴木 智之¹, 大内 美恵子¹, 後藤 百合子¹, 西條 芳文², 村山 伸樹³

Sachiko WATANABE¹, Namiko SUZUKI¹, Atuko KUDO¹, Tomoyuki SUZUKI¹, Mieko OHUCHI¹, Yuriko GOTOH¹, Yoshifumi SAIJO², Nobuki MURAYAMA³

¹宮城社会保険病院検査部, ²東北大学加齢医学研究所病態計測制御研究分野, ³熊本大学大学院自然科学研究科

¹Department of Laboratory, Miyagi Shakaihoken Hospital, ²Institute of Development, Aging and Cancer, Tohoku University, ³Graduate School of Science and Technology, Kumamoto University

キーワード : aging, diastolic function, Doppler echocardiography, echocardiography, systolic function

We assessed the influence of aging on cardiac function using echocardiography to measure systolic and diastolic function. The study group included 494 normal subjects aged 13 to 87 years. We detemined the ratio of E and A waves of left and right ventricular inflow (LV E/A, RV E/A), left ventricular ejection fraction (LVEF), and the ratio of the pre-ejection period and ejection time of the left ventricle (PEP/ET). Both LV E/A and RV E/A decreased significantly with age of subject. Rate of decline was greater in the LV E/A than in the RV E/A, but LVEF and PEP/ET were not significantly associated with aging. The results showed decline in the left and right ventricular diastolic function with age; however, left ventricular systolic function was not affected. The results also suggest that diastolic function is more sensitive than systolic function when the natural course of a large population is studied.