下浦 敬長¹, 本多 瑞枝², 西本 良博¹, 村木 登², 山崎 茂¹, 宿谷 正毅¹, 平井 昭², 増田 善昭¹, 稲垣 義明¹

Keicho SHIMOURA¹, Mizue HONDA², Yoshihiro NISHIMOTO¹, Noboru MURAKI², Shigeru YAMAZAKI¹, Masaki SHUKUYA¹, Akira HIRAI², Yoshiaki MASUDA¹, Yoshiaki INAGAKI¹

¹千葉大学医学部第三内科, ²千葉市立病院内科

¹The Third Department of Internal Medicine, Chiba University School of Medicine, ²Chiba Municipal Hospital

キーワード : amyl nitrite, ischemic heart disease, left ventricular function, non-invasive methods

Left ventricular function in 133 patients with ischemic heart disease and 25 normal subjects was studied non-invasively with amyl nitrite inhalation, and the data were compared with the findings of left ventriculography and coronary angiography which was performed in 60 patients.
The ischemic heart disease group showed a significantly less increase of ET/PEP, left ventricular posterior wall excursion, mean posterior wall velocity, ejection fraction and mean Vcf and a significantly less decrease of LV diastolic dimension with amyl nitrite inhalation comparing to the control group, and the difference of the myocardial function reserve between the groups was made obvious by amyl nitrite inhalation. Among them, the change of ET/PEP was the most reliable method of comprehensive left ventricular myocardial function assessment, and it correlated well to the severity of the disease assessed by cardiac catheterizations.
With a good understanding of the meaning of each hemodynamic parameter, amyl nitrite provocation enables a comprehensive and precise non-invasive assessment of the left ventricular function in ischemic heart diseases.