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英文誌(2004-)

Journal of Medical Ultrasonics

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1981 - Vol.8

Vol.8 No.02

Original Article(原著)

(0133 - 0140)

亜硝酸アミル負荷法による虚血性心疾患の左心機能評価 -超音波による検査法とSTI併用の意義-

Evaluation of left ventricular function in ischemic heart diseases by amyl nitrite inhalation with a special interest in a combination of echocardiography and systolic time intervals.

下浦 敬長1, 本多 瑞枝2, 西本 良博1, 村木 登2, 山崎 茂1, 宿谷 正毅1, 平井 昭2, 増田 善昭1, 稲垣 義明1

Keicho SHIMOURA1, Mizue HONDA2, Yoshihiro NISHIMOTO1, Noboru MURAKI2, Shigeru YAMAZAKI1, Masaki SHUKUYA1, Akira HIRAI2, Yoshiaki MASUDA1, Yoshiaki INAGAKI1

1千葉大学医学部第三内科, 2千葉市立病院内科

1The Third Department of Internal Medicine, Chiba University School of Medicine, 2Chiba Municipal Hospital

キーワード : amyl nitrite, ischemic heart disease, left ventricular function, non-invasive methods

Left ventricular function in 133 patients with ischemic heart disease and 25 normal subjects was studied non-invasively with amyl nitrite inhalation, and the data were compared with the findings of left ventriculography and coronary angiography which was performed in 60 patients.
The ischemic heart disease group showed a significantly less increase of ET/PEP, left ventricular posterior wall excursion, mean posterior wall velocity, ejection fraction and mean Vcf and a significantly less decrease of LV diastolic dimension with amyl nitrite inhalation comparing to the control group, and the difference of the myocardial function reserve between the groups was made obvious by amyl nitrite inhalation. Among them, the change of ET/PEP was the most reliable method of comprehensive left ventricular myocardial function assessment, and it correlated well to the severity of the disease assessed by cardiac catheterizations.
With a good understanding of the meaning of each hemodynamic parameter, amyl nitrite provocation enables a comprehensive and precise non-invasive assessment of the left ventricular function in ischemic heart diseases.